/* Briscoe Lab — site styles */

:root{
  --ink:#1A1919; --paper:#FFFFFF; --shell:#F7F6F5; --accent:#2B7871;
  --highlight:#D63849; --muted:#736D6E; --line:#E4E1E0;
  --serif:"Source Serif 4",Georgia,"Times New Roman",serif;
  --sans:"Inter",system-ui,-apple-system,"Segoe UI",sans-serif;
  --wrap:1200px; --prose:720px;
}

*{box-sizing:border-box;margin:0;padding:0}
html{scroll-behavior:smooth}
body{font-family:var(--sans);font-size:18px;line-height:1.6;color:var(--ink);
  background:var(--paper);-webkit-font-smoothing:antialiased}

h1,h2,h3,h4{font-family:var(--serif);font-weight:600;line-height:1.15;letter-spacing:-.01em}
h1{font-size:48px} h2{font-size:34px} h3{font-size:26px} h4{font-size:20px}
p{margin-bottom:1.1em}
img{max-width:100%;height:auto;display:block}

a{color:var(--accent);text-decoration:none;border-bottom:1px solid rgba(43,120,113,.32)}
a:hover{border-bottom-color:var(--accent)}
a:focus-visible,button:focus-visible{outline:3px solid var(--highlight);outline-offset:3px}

.skip{position:absolute;left:-9999px;top:0;background:var(--ink);color:#fff;padding:12px 20px;z-index:100;border:0}
.skip:focus{left:0}

.wrap{max-width:var(--wrap);margin:0 auto;padding:0 32px}
.prose{max-width:var(--prose)}
.sec{padding:96px 0}
/* two prose sections on the same background that read as one block */
.sec--runin{padding-bottom:52px}
.sec--runon{padding-top:0}
.sec--tight{padding:64px 0}
.shell{background:var(--shell)}
.eyebrow{font-size:13px;font-weight:600;letter-spacing:.09em;text-transform:uppercase;color:var(--muted);margin-bottom:14px}
.lede{font-size:22px;line-height:1.5}
.muted{color:var(--muted)}
.small{font-size:15px}
.credit{font-size:12.5px;color:var(--muted)}
hr{border:0;border-top:1px solid var(--line)}

/* ---------- header ---------- */
header{position:sticky;top:0;z-index:50;background:rgba(255,255,255,.96);
  backdrop-filter:blur(8px);border-bottom:1px solid var(--line)}
.brand{display:flex;align-items:center;gap:12px}
.mark-logo{height:44px;width:auto;flex:none}
@media(max-width:900px){.mark-logo{height:36px}}
.bar{max-width:var(--wrap);margin:0 auto;padding:0 32px;height:74px;
  display:flex;align-items:center;justify-content:space-between;gap:20px}
.mark{font-family:var(--serif);font-size:23px;font-weight:600;letter-spacing:-.02em;color:var(--ink);border:0}
.mark em{display:block;font-family:var(--sans);font-size:11px;font-style:normal;font-weight:500;
  letter-spacing:.07em;text-transform:uppercase;color:var(--muted);margin-top:2px}
nav ul{display:flex;list-style:none;gap:2px;align-items:center}
nav a{font-size:15px;font-weight:500;color:var(--ink);border:0;padding:9px 12px;border-radius:6px;display:block}
nav a:hover{background:var(--shell)}
nav a[aria-current="page"],nav a.on{color:var(--accent);background:var(--shell)}
.dd{position:relative}
.dd>a::after{content:"";display:inline-block;width:5px;height:5px;
  border-right:1.5px solid var(--muted);border-bottom:1.5px solid var(--muted);
  transform:rotate(45deg);margin-left:7px;vertical-align:2px}
.dd>ul{display:none;position:absolute;top:100%;left:0;background:#fff;border:1px solid var(--line);
  border-radius:8px;padding:7px;min-width:300px;flex-direction:column;box-shadow:0 8px 28px rgba(20,24,28,.09)}
.dd:hover>ul,.dd:focus-within>ul{display:flex}
.dd>ul a{font-weight:400;font-size:14.5px;padding:8px 12px}
.burger{display:none;background:none;border:1px solid var(--line);border-radius:6px;
  padding:9px 12px;font-size:14px;cursor:pointer;font-family:var(--sans)}

/* ---------- buttons ---------- */
.btn{display:inline-block;font-size:15px;font-weight:500;padding:13px 24px;border-radius:6px;
  border:1px solid var(--accent);background:var(--accent);color:#fff}
.btn:hover{background:#215f5a;border-bottom-color:#215f5a}
.btn--light{background:#fff;color:var(--ink);border-color:#fff}
.btn--light:hover{background:#EFEDEB;border-bottom-color:#EFEDEB}
.btn--outline-light{background:transparent;color:#fff;border-color:rgba(255,255,255,.6)}
.btn--outline-light:hover{background:rgba(255,255,255,.12);border-bottom-color:rgba(255,255,255,.6)}

/* ---------- hero and page headers ---------- */
.hero,.phead{position:relative;overflow:hidden;background:#121110}
.hero{height:580px}
.phead{height:330px}
.hero>img,.phead>img,.hero>picture,.hero>picture>img{position:absolute;inset:0;width:100%;height:100%;object-fit:cover}
.veil{position:absolute;inset:0;
  background:linear-gradient(90deg,rgba(18,17,16,.92) 0%,rgba(18,17,16,.76) 38%,rgba(18,17,16,.15) 72%,rgba(18,17,16,0) 100%)}
.hero .in{position:relative;height:100%;display:flex;align-items:center}
.phead .in{position:relative;height:100%;display:flex;align-items:flex-end;padding-bottom:38px}
.phead--pale{background:var(--shell)}
.phead--pale .veil{background:linear-gradient(90deg,rgba(247,246,245,.96) 0%,rgba(247,246,245,.8) 45%,rgba(247,246,245,.1) 100%)}
.hero h1{color:#fff;font-size:52px;line-height:1.08;margin-bottom:32px}
.hero p{color:rgba(255,255,255,.88);font-size:21px;line-height:1.5;margin:22px 0 30px;max-width:560px}
.phead h1{color:#fff}
.phead--pale h1{color:var(--ink)}
.phead--pale .eyebrow{color:var(--muted)}
.phead .eyebrow{color:rgba(255,255,255,.75)}

/* ---------- grids and cards ---------- */
.grid{display:grid;gap:28px}
.g2{grid-template-columns:repeat(2,minmax(0,1fr))}
.g3{grid-template-columns:repeat(3,minmax(0,1fr))}
.g4{grid-template-columns:repeat(4,minmax(0,1fr))}
.card{border:1px solid var(--line);border-radius:8px;overflow:hidden;background:#fff;display:flex;flex-direction:column;
  transition:transform .28s ease,box-shadow .28s ease,border-color .28s ease}
.card:hover{transform:translateY(-3px);box-shadow:0 10px 26px rgba(20,24,28,.09);border-color:#D6D2D1}
.card>img{height:180px;width:100%;object-fit:cover;transition:transform .55s ease}
.card:hover>img{transform:scale(1.045)}

/* sections rise into view; the reduced-motion block below disables this */
.reveal{opacity:0;transform:translateY(38px) scale(.985);
  transition:opacity .78s cubic-bezier(.16,.7,.28,1),transform .78s cubic-bezier(.16,.7,.28,1)}
.reveal.in{opacity:1;transform:none}
@media (prefers-reduced-motion: reduce){.reveal{opacity:1;transform:none}}

/* Cross-fading hero frames that drift continuously.
   Each frame holds two copies of its image side by side in a track. The track
   travels exactly one image width and repeats, so the second copy lands where the
   first began and the loop is invisible. The images have their left and right
   edges faded to black, so the join between copies cannot be seen. */
@keyframes heroWrap{from{transform:translateX(0)}to{transform:translateX(-50%)}}
.hero-frame{position:absolute;inset:0;overflow:hidden;opacity:0;transition:opacity 1.9s ease-in-out}
.hero-frame.is-on{opacity:1}
.hero-track{position:absolute;top:0;left:0;height:100%;width:200%;display:flex}
.hero-track>*{width:50%;height:100%;flex:none;position:relative}
.hero-track img{width:100%;height:100%;object-fit:cover;display:block}
@media (prefers-reduced-motion: no-preference){
  .hero-track{animation:heroWrap 90s linear infinite;will-change:transform}
}
@media (max-width:700px){.hero .hero-frame:not(:first-child){display:none}}
@media (prefers-reduced-motion: reduce){
  .hero .hero-frame:not(:first-child){display:none}
  .hero .hero-frame:first-child{opacity:1}
  .hero-track{width:100%}
  .hero-track>*:last-child{display:none}
}
.card-b{padding:22px;flex:1;display:flex;flex-direction:column}
.card h3,.card h4{margin-bottom:9px}
.card p{font-size:15.5px;line-height:1.55;color:var(--muted);margin-bottom:14px;flex:1}
.card .go{font-size:14px;font-weight:500;border:0}
.ph{background:#E4E1E0;border-radius:6px;display:flex;align-items:flex-end;padding:14px}

/* ---------- featured paper ---------- */
.feature{background:var(--shell);border-left:4px solid var(--accent);border-radius:0 6px 6px 0;
  padding:24px 28px;margin:34px 0}
.feature .feature-t{font-family:var(--serif);font-size:20px;font-weight:600;
  line-height:1.2;letter-spacing:-.01em;margin-bottom:10px;color:var(--ink)}
.feature p{font-size:16px;line-height:1.6;margin-bottom:10px}
.feature .cite{font-size:14px;color:var(--muted);margin:0}

/* ---------- figures ---------- */
figure{margin:32px 0}
figure img{border:1px solid var(--line);border-radius:6px;background:#fff}
figcaption{font-size:14px;line-height:1.5;color:var(--muted);margin-top:10px}
figcaption b{color:var(--ink);font-weight:600}

/* ---------- people ---------- */
.pgrid{display:grid;grid-template-columns:repeat(4,minmax(0,1fr));gap:26px 24px}
.person .av{aspect-ratio:1;border-radius:6px;background:var(--shell);display:flex;align-items:center;
  justify-content:center;font-family:var(--serif);font-size:32px;font-weight:600;color:#A8A3A2;
  margin-bottom:12px;border:1px solid var(--line);overflow:hidden}
.person .av img{width:100%;height:100%;object-fit:cover;display:block}
.person .ph{aspect-ratio:1;border-radius:6px;margin-bottom:12px;border:1px solid var(--line);overflow:hidden}
.person .ph img{width:100%;height:100%;object-fit:cover}
.person .nm{font-weight:600;font-size:16px;line-height:1.3}
.person .rl{font-size:14px;color:var(--muted);margin-top:2px}
.person .bio{font-size:13.5px;line-height:1.55;margin-top:7px}
.person .em{font-size:13px;color:var(--muted);margin-top:5px;word-break:break-all}
.person .lk{margin-top:6px;font-size:13px;color:var(--muted)}
.person .lk a{white-space:nowrap}
.alum-row{padding:13px 0;border-bottom:1px solid var(--line)}

/* ---------- publications ---------- */
.pub{padding:20px 0;border-bottom:1px solid var(--line);max-width:820px}
.pub .au{font-size:15px;color:var(--muted);margin-bottom:4px}
.pub .ti{font-size:17px;font-weight:600;line-height:1.4;margin-bottom:5px}
.pub .jr{font-size:15px;color:var(--muted);font-style:italic}
.pub .ln{margin-top:9px;display:flex;gap:8px;flex-wrap:wrap;align-items:center}
.pub .why{border-left:3px solid var(--highlight);padding-left:16px;margin-top:10px;font-size:15px;color:var(--muted)}
.tag{font-size:12px;font-weight:500;padding:4px 10px;border-radius:20px;background:var(--shell);
  color:var(--muted);border:1px solid var(--line);display:inline-block}
a.tag{border-bottom:1px solid var(--line)}
.filters{display:flex;gap:9px;flex-wrap:wrap;align-items:center;margin-bottom:12px}
.pill{font-size:13px;font-weight:500;padding:7px 15px;border-radius:20px;border:1px solid var(--line);
  background:#fff;cursor:pointer;font-family:var(--sans);color:var(--muted)}
.pill[aria-pressed="true"]{background:var(--accent);color:#fff;border-color:var(--accent)}
.yearhead{font-family:var(--serif);font-size:22px;font-weight:600;margin:34px 0 4px;
  padding-bottom:8px;border-bottom:2px solid var(--ink);max-width:820px}
.note{border-left:3px solid var(--highlight);padding-left:18px;font-size:15px;color:var(--muted)}

/* ---------- interactive neural tube ---------- */
.ntube{display:grid;grid-template-columns:300px 1fr;gap:44px;align-items:center;max-width:900px}
.ntube svg{width:100%;height:auto;display:block}
.ntube-ctl{margin-bottom:26px}
.ntube-ctl label{display:block;font-size:14px;font-weight:600;margin-bottom:2px}
.ntube-ctl .hint{font-size:13.5px;color:var(--muted);margin-bottom:10px}
.ntube-ctl input[type=range]{width:100%;accent-color:var(--accent);height:24px}
.ntube-read{font-size:14.5px;line-height:1.6;border-left:3px solid var(--accent);
  padding-left:16px;color:var(--ink);min-height:52px}
.ntube-read b{font-weight:600}
.ntube-key{display:flex;flex-wrap:wrap;gap:7px 14px;margin-top:16px;font-size:13px;color:var(--muted)}
.ntube-key span{display:flex;align-items:center;gap:6px}
.ntube-key i{width:11px;height:11px;border-radius:2px;display:inline-block}
@media(max-width:760px){.ntube{grid-template-columns:1fr;gap:28px;max-width:420px}}

/* ---------- blog ---------- */
.post-meta{font-size:15px;color:var(--muted);margin-bottom:26px}
.post-meta a{color:var(--muted)}
.gal{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:26px 22px;margin:36px 0}
.gal figure{margin:0}
.gal img{width:100%;height:auto;border-radius:5px;background:var(--shell)}
.gal figcaption{font-size:13.5px;color:var(--muted);margin-top:7px;line-height:1.45}
@media(max-width:820px){.gal{grid-template-columns:repeat(2,minmax(0,1fr))}}
@media(max-width:520px){.gal{grid-template-columns:1fr}}
.postnav{display:flex;justify-content:space-between;gap:24px;flex-wrap:wrap;
  padding-top:26px;border-top:1px solid var(--line);margin-top:44px;font-size:15px}

/* ---------- deposited datasets ---------- */
.ds{padding:22px 0;border-bottom:1px solid var(--line);max-width:820px}
.ds .acc{font-size:17px;font-weight:600;line-height:1.35;margin-bottom:4px}
.ds .src{font-size:15px;color:var(--muted);font-style:italic;margin-bottom:9px}
.ds .desc{font-size:15.5px;line-height:1.6;margin:0}
.ds .ln{margin-top:11px;display:flex;gap:8px;flex-wrap:wrap;align-items:center}

/* ---------- footer ---------- */
footer{background:var(--ink);color:#CECBCA;padding:70px 0 30px;font-size:15px}
footer h2{font-size:12px;font-weight:600;letter-spacing:.09em;text-transform:uppercase;
  color:#8D8C8C;margin-bottom:16px;font-family:var(--sans)}
footer a{color:#CECBCA;border:0}
footer a:hover{color:#fff;text-decoration:underline}
footer .fm{font-family:var(--serif);font-size:22px;font-weight:600;color:#fff;margin-bottom:10px}
footer ul{list-style:none;line-height:2}
.fbar{border-top:1px solid #383838;margin-top:52px;padding-top:24px;display:flex;
  justify-content:space-between;gap:20px;flex-wrap:wrap;font-size:13.5px;color:#8D8C8C}

/* ---------- responsive ---------- */
@media(max-width:900px){
  body{font-size:17px}
  h1{font-size:34px} h2{font-size:27px} h3{font-size:22px}
  .wrap{padding:0 20px}
  .bar{padding:0 20px;height:64px}
  .burger{display:block}
  nav{position:absolute;top:64px;left:0;right:0;background:#fff;border-bottom:1px solid var(--line);
    padding:12px 20px 20px;display:none}
  nav.open{display:block}
  nav ul{flex-direction:column;align-items:stretch;gap:0}
  nav a{padding:12px 4px;border-bottom:1px solid var(--line);border-radius:0}
  .dd>a::after{display:none}
  .dd>ul{display:flex;position:static;border:0;box-shadow:none;padding:0 0 0 16px;min-width:0}
  .sec{padding:56px 0}
  .g2,.g3,.g4{grid-template-columns:1fr}
  .pgrid{grid-template-columns:repeat(2,minmax(0,1fr))}
  .hero{height:auto;min-height:440px}
  .hero h1{font-size:34px;margin-bottom:24px}
  .hero p{font-size:18px}
  .phead{height:220px}
  .lede{font-size:19px}
  .veil{background:linear-gradient(180deg,rgba(18,17,16,.5),rgba(18,17,16,.9))}
  .phead--pale .veil{background:linear-gradient(180deg,rgba(247,246,245,.6),rgba(247,246,245,.95))}
  .hero .in{padding:56px 0}
}

@media (prefers-reduced-motion: reduce){
  html{scroll-behavior:auto}
  *{transition:none!important;animation:none!important}
}

.sr-only-h2{position:absolute;width:1px;height:1px;padding:0;margin:-1px;overflow:hidden;clip:rect(0 0 0 0);white-space:nowrap;border:0}

.funding{margin-top:44px;font-size:13.5px;line-height:1.65;color:#8D8C8C;max-width:940px}

.map{position:relative;aspect-ratio:4/3;border-radius:6px;overflow:hidden;background:var(--shell);
  border:1px solid var(--line);display:flex;align-items:center;justify-content:center}
.map iframe{position:absolute;inset:0;width:100%;height:100%;border:0}
.map img{position:absolute;inset:0;width:100%;height:100%;object-fit:cover}
.map-load{position:relative;background:rgba(255,255,255,.94);border:1px solid var(--line);
  border-radius:6px;padding:16px 22px;box-shadow:0 2px 14px rgba(20,24,28,.18);
  font-family:var(--sans);font-size:15px;font-weight:500;color:var(--ink);cursor:pointer;
  text-align:center;max-width:80%;line-height:1.4}
.map-load:hover{border-color:var(--accent);color:var(--accent)}
.map-load span{display:block;font-size:13px;font-weight:400;color:var(--muted);margin-top:6px}