ORCID ID: 0000-0002-1020-5240
Metzis V, Steinhauser S, Pakanavicius E, Gouti M, Stamataki D, Ivanovitch K, Watson T, Rayon T, Mousavy Gharavy SN, Lovell-Badge R, Luscombe NM, Briscoe J. (2018)
Nervous System Regionalization Entails Axial Allocation before Neural Differentiation.
Cell 175: 1105-1118 PubMed abstract
Frith TJ, Granata I, Wind M, Stout E, Thompson O, Neumann K, Stavish D, Heath PR, Ortmann D, Hackland JO, Anastassiadis K, Gouti M, Briscoe J, Wilson V, Johnson SL, Placzek M, Guarracino MR, Andrews PW, Tsakiridis A. (2018)
Human axial progenitors generate trunk neural crest cells in vitro.
Elife 7. pii: e35786 PubMed abstract
Ebisuya M, Briscoe J. (2018)
What does time mean in development?
Development 145. pii: dev164368 PubMed abstract
Gabryšová, L; Alvarez-Martinez, M; Luisier, R; Cox, LS; Sodenkamp, J; Hosking, C; Pérez-Mazliah, D; Whicher, C; Kannan, Y; Potempa, K; Wu, X; Bhaw, L; Wende, H; Sieweke, MH; Elgar, G; Wilson, M; Briscoe, J; Metzis, V; Langhorne, J; Luscombe, NM and O’Garra, A (2018)
c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells.
Nature Immunology 19:497-507 PubMed abstract
Perez-Carrasco R, Barnes CP, Schaerli Y, Isalan M, Briscoe J, Page KM. (2018)
Combining a Toggle Switch and a Repressilator within the AC-DC Circuit Generates Distinct Dynamical Behaviors
Cell Systems 6:521-530. PubMed abstract
M Placzek, J Briscoe. (2018)
Sonic hedgehog in vertebrate neural tube development
International Journal of Developmental Biology 62:221-230 PubMed abstract
Herrera-Delgado E, Perez-Carrasco R, Briscoe J, Sollich P. (2018)
Memory functions reveal structural properties of gene regulatory networks.
PLoS Computational Biology 14:e1006003. PubMed abstract
Pusapati GV, Kong JH, Patel BB, Gouti M, Sagner A, Sircar R, Luchetti G, Ingham PW, Briscoe J, Rohatgi R. (2018)
G protein-coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog.
Science Signal. 11 pii: eaao5749 PubMed abstract
Sagner A, Gaber ZB, Delile J, Kong JH, Rousso DL, Pearson CA, Weicksel SE, Melchionda M, Mousavy Gharavy SN, Briscoe J, Novitch BG. (2018)
Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics.
PLoS Biology 16:e2003127. PubMed abstract
Blassberg, R and Briscoe, J (2018)
Smoothened sensor places sodium and sterols center stage.
Developmental Cell 44, 3-4 PubMed abstract
Pusapati, GV; Kong, JH; Patel, BB; Krishnan, A; Sagner, A; Kinnebrew, M; Briscoe, J; Aravind, L and Rohatgi, R (2018)
CRISPR screens uncover genes that regulate target cell sensitivity to the morphogen Sonic Hedgehog.
Developmental Cell 44, 113-129 PubMed abstract
Zagorski, M; Tabata, Y; Brandenberg, N; Lutolf, MP; Tkačik, G; Bollenbach, T; Briscoe, J and Kicheva, A (2017)
Decoding of position in the developing neural tube from antiparallel morphogen gradients.
Science 356, 1379-1383 PubMed abstract
Desplan, C; Plachta, N; Monteiro, A; Guillemin, K and Briscoe, J (2017)
What is the future of developmental biology?
Cell 170, 6-7
Gouti, M; Delile, J; Stamataki, D; Wymeersch, FJ; Huang, Y; Kleinjung, J; Wilson, V and Briscoe, J (2017)
A gene regulatory network balances neural and mesoderm specification during vertebrate trunk development.
Developmental Cell 41, 243-261 PubMed abstract
Briscoe J, Kicheva A (2017)
The physics of development 100 years after D’Arcy Thompson’s “On Growth and Form”
Mechanisms of Development 145,26-31 PubMed abstract
Sagner A, Briscoe J (2017)
Morphogen interpretation: concentration, time, competence, and signaling dynamics.
Wiley Interdiscip Rev Dev Biol. doi: 10.1002/wdev.271 PubMed abstract
Perez-Carrasco R, Guerrero P, Briscoe J, Page KM (2016)
Intrinsic Noise Profoundly Alters the Dynamics and Steady State of Morphogen-Controlled Bistable Genetic Switches.
PLoS Comput Biol 12: e1005154 PubMed abstract
Demers CJ, Soundararajan P, Chennampally P, Cox GA, Briscoe J, Collins SD, Smith RL (2016)
Development-on-chip: in vitro neural tube patterning with a
Development 143,1884-9 PubMed abstract
Cohen M, Page KM, Perez-Carrasco R, Barnes CP, Briscoe J (2016)
Mathematical models help explain experimental data.
Development 143,1640-3 PubMed abstract
Uygur, A; Young, J; Huycke, TR; Koska, M; Briscoe, J and Tabin, CJ (2016)
Scaling pattern to variations in size during development of the vertebrate neural tube.
Developmental Cell 37, 127-135 PubMed abstract
Kutejova, E; Sasai, N; Shah, A; Gouti, M; Briscoe J. (2016)
Neural Progenitors Adopt Specific Identities by Directly Repressing All Alternative Progenitor Transcriptional Programs.
Developmental Cell 36, 639–665 PubMed abstract
Blassberg, R; MacRae, JI; Briscoe, J and Jacob, J (2015)
Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz Syndrome.
Human Molecular Genetics [Epub ahead of print] PubMed abstract
Briscoe, J (2015)
Morphogens, modeling and patterning the neural tube: an interview with James Briscoe.
BMC Biology 13, 5 PubMed abstract
Briscoe, J and Small, S (2015)
Morphogen rules: design principles of gradient-mediated embryo patterning.
Development 142, 3996-4009 PubMed abstract
Cohen, M; Kicheva, A; Ribeiro, A; Blassberg, R; Page, KM; Barnes, CP and Briscoe, J (2015)
Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms.
Nature Communications 6, 6709 PubMed abstract
Gouti, M; Metzis, V and Briscoe, J (2015)
The route to spinal cord cell types: a tale of signals and switches.
Trends in Genetics 31, 282-289 PubMed abstract
Kicheva, A and Briscoe, J (2015)
Developmental pattern formation in phases.
Trends in Cell Biology 25, 579-591 PubMed abstract
Kong, JH; Yang, L; Dessaud, E; Chuang, K; Moore, DM; Rohatgi, R; Briscoe, J and Novitch, BG (2015)
Notch activity modulates the responsiveness of neural progenitors to Sonic hedgehog signaling.
Developmental Cell 33, 373-387 PubMed abstract
Cohen, M; Page, KM; Perez-Carrasco, R; Barnes, CP and Briscoe, J (2014)
A theoretical framework for the regulation of Shh morphogen-controlled gene expression.
Development 141, 3868-3878 PubMed abstract
Goggolidou, P; Stevens, JL; Agueci, F; Keynton, J; Wheway, G; Grimes, DT; Patel, SH; Hilton, H; Morthorst, SK; DiPaolo, A; Williams, DJ; Sanderson, J; Khoronenkova, SV; Powles-Glover, N; Ermakov, A; Esapa, CT; Romero, R; Dianov, GL; Briscoe, J; Johnson, CA; Pedersen, LB and Norris, DP (2014)
ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis.
Development 141, 3966-3977 PubMed abstract
Gouti, M; Tsakiridis, A; Wymeersch, FJ; Huang, Y; Kleinjung, J; Wilson, V and Briscoe, J (2014)
In vitro generation of neuromesodermal progenitors reveals distinct roles for Wnt signalling in the specification of spinal cord and paraxial mesoderm identity.
PLOS Biology 12, e1001937 PubMed abstract
Jacob, J; Ribes, V; Moore, S; Constable, SC; Sasai, N; Gerety, SS; Martin, DJ; Sergeant, CP; Wilkinson, DG and Briscoe, J (2014)
Valproic acid silencing of ascl1b/Ascl1 results in the failure of serotonergic differentiation in a zebrafish model of fetal valproate syndrome.
Disease Models & Mechanisms 7, 107-117 PubMed abstract
Kicheva, A; Bollenbach, T; Ribeiro, A; Valle, HP; Lovell-Badge, R; Episkopou, V and Briscoe, J (2014)
Coordination of progenitor specification and growth in mouse and chick spinal cord.
Science 345, 1254927 PubMed abstract
Sasai, N; Kutejova, E and Briscoe, J (2014)
Integration of signals along orthogonal axes of the vertebrate neural tube controls progenitor competence and increases cell diversity.
PLOS Biology 12, e1001907 PubMed abstract
Briscoe, J and Thérond, PP (2013)
The mechanisms of Hedgehog signalling and its roles in development and disease.
Nature Reviews Molecular Cell Biology 14, 416-429 PubMed abstract
Briscoe, J and Vincent, J-P (2013)
Hedgehog threads to spread.
Nature Cell Biology 15, 1265-1267 PubMed abstract
Cohen, M; Briscoe, J and Blassberg, R (2013)
Morphogen interpretation: the transcriptional logic of neural tube patterning.
Current Opinion in Genetics & Development 23, 423-428 PubMed abstract
Gerety, SS; Breau, MA; Sasai, N; Xu, Q; Briscoe, J and Wilkinson, DG (2013)
An inducible transgene expression system for zebrafish and chick.
Development 140, 2235-2243 PubMed abstract
Jacob, J; Kong, J; Moore, S; Milton, C; Sasai, N; Gonzalez-Quevedo, R; Terriente, J; Imayoshi, I; Kageyama, R; Wilkinson, David G; Novitch, Bennett G and Briscoe, J (2013)
Retinoid acid specifies neuronal identity through graded expression of Ascl1.
Current Biology 23, 412-418 PubMed abstract
Kahane, N; Ribes, V; Kicheva, A; Briscoe, J and Kalcheim, C (2013)
The transition from differentiation to growth during dermomyotome-derived myogenesis depends on temporally restricted hedgehog signaling.
Development 140, 1740-1750 PubMed abstract
Liu, JAJ; Wu, M-H; Yan, CH; Chau, BKH; So, H; Ng, A; Chan, A; Cheah, KSE; Briscoe, J and Cheung, M (2013)
Phosphorylation of Sox9 is required for neural crest delamination and is regulated downstream of BMP and canonical Wnt signaling.
Proceedings of the National Academy of Sciences of the United States of America 110, 2882-2887 PubMed abstract
Moore, S; Ribes, V; Terriente, J; Wilkinson, D; Relaix, F and Briscoe, J (2013)
Distinct regulatory mechanisms act to establish and maintain Pax3 expression in the developing neural tube.
PLOS Genetics 9, e1003811 PubMed abstract
Panovska-Griffiths, J; Page, KM and Briscoe, J (2013)
A gene regulatory motif that generates oscillatory or multiway switch outputs.
Journal of the Royal Society Interface 10, 20120826
Tozer, S; Le Dréau, G; Marti, E and Briscoe, J (2013)
Temporal control of BMP signalling determines neuronal subtype identity in the dorsal neural tube.
Development 140, 1467-1474 PubMed abstract
Balaskas, N; Ribeiro, A; Panovska, J; Dessaud, E; Sasai, N; Page, Karen M; Briscoe, J and Ribes, V (2012)
Gene regulatory logic for reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube.
Cell 148, 273-284 PubMed abstract
Briscoe, J and Rohatgi, R (2012)
Singapore signalling: the 2012 hedgehog pathway cocktail.
EMBO Reports 13, 580-583 PubMed abstract
Briscoe, J and Sharpe, J (2012)
Genetics of system biology.
Current Opinion in Genetics & Development 22, 523-526 PubMed abstract
Bushati, N and Briscoe, J (2012)
Regulation of Neuronal Subtype Identity in the Vertebrate Neural Tube (Neuronal Subtype Identity Regulation).
John Wiley & Sons, Ltd, 2012.
Kicheva, A; Bollenbach, T; Wartlick, O; Julicher, F and Gonzalez-Gaitan, M (2012)
Investigating the principles of morphogen gradient formation: from tissues to cells.
Current Opinion in Genetics & Development 22, 527-532 PubMed abstract
Kicheva, A; Cohen, M and Briscoe, J (2012)
Developmental pattern formation: insights from physics and biology.
Science 338, 210-212 PubMed abstract
Le Dréau, G; Garcia-Campmany, L; Rabadán, MA; Ferronha, T; Tozer, S; Briscoe, J and Marti, E (2012)
Canonical BMP7 activity is required for the generation of discrete neuronal populations in the dorsal spinal cord.
Development 139, 259-268 PubMed abstract
Matheu, A; Collado, M; Wise, C; Manterola, L; Cekaite, L; Tye, AJ; Canamero, M; Bujanda, L; Schedl, A; Cheah, KSE; Skotheim, RI; Lothe, RA; López de Munain, A; Briscoe, J; Serrano, M and Lovell-Badge, R (2012)
Oncogenicity of the developmental transcription factor Sox9.
Cancer Research 72, 1301-1315 PubMed abstract
Rabadán, MA; Cayuso, J; Le Dréau, G; Cruz, C; Barzi, M; Pons, S; Briscoe, J and Martí, E (2012)
Jagged2 controls the generation of motor neuron and oligodendrocyte progenitors in the ventral spinal cord.
Cell Death and Differentiation 19, 209-219 PubMed abstract
Sasai, N and Briscoe, J (2012)
Primary cilia and graded Sonic Hedgehog signaling.
Wiley Interdisciplinary Reviews: Developmental Biology 1, 753-772 PubMed abstract
Bangs, F; Antonio, N; Thongnuek, P; Welten, M; Davey, MG; Briscoe, J and Tickle, C (2011)
Generation of mice with functional inactivation of talpid3, a gene first identified in chicken.
Development 138, 3261-3272 PubMed abstract
Bushati, N; Smith, J; Briscoe, J and Watkins, C (2011)
An intuitive graphical visualization technique for the interrogation of transcriptome data.
Nucleic Acids Research 39, 7380-7389
Chen, Y; Sasai, N; Ma, G; Yue, T; Jia, J; Briscoe, J and Jiang, J (2011)
Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened.
PLOS Biology 9, e20977 PubMed abstract
Escudero, LM; da, FC, L.; Kicheva, A; Briscoe, J; Freeman, M and Babu, MM (2011)
Epithelial organisation revealed by a network of cellular contacts.
Nature Communications 2, 526 PubMed abstract
Gouti, M; Briscoe, J and Gavalas, A (2011)
Anterior hox genes interact with components of the neural crest specification network to induce neural crest fates.
Stem Cells 29, 858-870 PubMed abstract
Stamataki, D; Holder, M; Hodgetts, C; Jeffery, R; Nye, E; Spencer-Dene, B; Winton, DJ and Lewis, J (2011)
Delta1 expression, cell cycle exit, and commitment to a specific secretory fate coincide within a few hours in the mouse intestinal stem cell system.
PLOS ONE 6, e24484
Briscoe, J; Lawrence, PA and Vincent, JP (editors).
Generation and Interpretation of Morphogen Gradients.
New York, Cold Spring Harbor Laboratory Press, 2010.
Cox, B; Briscoe, J and Ulloa, F (2010)
SUMOylation by Pias1 regulates the activity of the Hedgehog dependent Gli transcription factors.
PLOS ONE 5, e11996 PubMed abstract
Cruz, C; Ribes, V; Kutejova, E; Cayuso, J; Lawson, V; Norris, D; Stevens, J; Davey, M; Blight, K; Bangs, F; Mynett, A; Hirst, E; Chung, R; Balaskas, N; Brody, SL; Marti, E and Briscoe, J (2010)
Foxj1 regulates floor plate cilia architecture and modifies the response of cells to sonic hedgehog signalling.
Development 137, 4271-4282 PubMed abstract
Dessaud, E; Ribes, V; Balaskas, N; Yang, LL; Pierani, A; Kicheva, A; Novitch, BG; Briscoe, J and Sasai, N (2010)
Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen Sonic hedgehog.
PLOS Biology 8, e1000382 PubMed abstract
Kicheva, A and Briscoe, J (2010)
Limbs made to measure.
PLOS Biology 8, e1000421 PubMed abstract
Ribes, V; Balaskas, N; Sasai, N; Cruz, C; Dessaud, E; Cayuso, J; Tozer, S; Yang, LL; Novitch, B; Marti, E and Briscoe, J (2010)
Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube.
Genes & Development 24, 1186-1200 PubMed abstract
Scott, CE; Wynn, SL; Sesay, A; Cruz, C; Cheung, M; Gaviro, M-VG; Booth, S; Gao, B; Cheah, KSE; Lovell-Badge, R and Briscoe, J (2010)
SOX9 induces and maintains neural stem cells.
Nature Neuroscience 13, 1181-1189 PubMed abstract
Zhu, D; Jarmin, S; Ribeiro, A; Prin, F; Xie, SQ; Sullivan, K; Briscoe, J; Gould, AP; Marelli-Berg, FM and Gu, Y (2010)
Applying an adaptive watershed to the tissue cell quantification during T-cell migration and embryonic development.
Methods in Molecular Biology 616, 207-228 PubMed abstract