Publications
121 papers, 2010 to 2026. ORCID 0000-0002-1020-5240 · Google Scholar
Theme
Year
2026
Radley A, Boezio GLM, Shand C, Perez-Carrasco R, Briscoe J
Entropy Sorting Feature Selection: information-theoretic gene set identification improves single-cell RNA sequencing data interpretability
bioRxiv (2026)
Stuart HT, Costantini E, Wang J, et al., Tanaka EM, Briscoe J
Minimal essential requirements for neural tube self-organisation
bioRxiv (2026)
Maizels RJ, Briscoe J
Gene regulatory networks: from correlative models to causal explanations
Nature Reviews Genetics 27(6):485-498
2025
Fontaine M, Delás MJ, Saez M, Maizels RJ, Finnie E, Briscoe J, Rand DA
Dynamic landscape analysis of cell fate decisions: predictive models of neural development from single-cell data
bioRxiv (2025)
Cornwall-Scoones J, Benzinger D, Yu T, et al., Briscoe J, Delás MJ
Predictable engineering of signal-dependent cis-regulatory elements
bioRxiv (2025)
Boezio GLM, Depotter JRL, Frith TJR, Radley A, Strohbuecker S, Cunha AC, Howell M, Briscoe J
Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding
bioRxiv (2025)
Cislo DJ, Delás MJ, Briscoe J, Siggia ED
Reconstructing Waddington's landscape from data
Proceedings of the National Academy of Sciences USA 122(49):e2521762122
Hamrud E, Leese J, Thiery AP, Buzzi AL, Vigilante A, Briscoe J, Streit A
Dynamic changes in chromatin accessibility during cell fate specification at the neural plate border
Development 152(23):dev204943
Inge OCK, Copin E, Cornwall-Scoones J, Gharibi B, Rodriguez-Hernandez I, Soro-Barrio P, Strom M, Chakravarty P, Briscoe J, Santos SDM
Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation
Developmental Cell 60(23):3304-3320.e9
Benzinger D, Briscoe J
Investigating morphogen and patterning dynamics with optogenetic control of morphogen production
Developmental Cell 60(24):3421-3430.e6
Zhang I, Boezio GLM, Cornwall-Scoones J, Frith T, Finnie E, Luo J, Jiang M, Howell M, Lovell-Badge R, Sagner A, Briscoe J, Delás MJ
The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube
Developmental Cell 60(22):3034-3049.e9
Libby ARG, Rito T, Radley A, Briscoe J
An in vivo CRISPR screen in chick embryos reveals a role for MLLT3 in specification of neural cells from the caudal epiblast
Development 152(3):dev204591
Rito T, Libby ARG, Demuth M, Domart MC, Cornwall-Scoones J, Briscoe J
Timely TGFβ signalling inhibition induces notochord
Nature 637(8046):673-682
2024
Maizels RJ, Snell DM, Briscoe J
A protocol for time-resolved transcriptomics through metabolic labeling and combinatorial indexing
STAR Protocols 5:103356
PubMed Computational approaches
Lebek T, Malaguti M, Boezio GL, Zoupi L, Briscoe J, Elfick A, Lowell S
PUFFFIN: an ultra-bright, customisable, single-plasmid system for labelling cell neighbourhoods
EMBO Journal 43(18):4110-4135
Krammer T, Stuart HT, Gromberg E, Ishihara K, Cislo D, Melchionda M, Becerril Perez F, Wang J, Costantini E, Lehr S, Arbanas L, Hörmann A, Neumüller RA, Elvassore N, Siggia E, Briscoe J, Kicheva A, Tanaka EM
Mouse neural tube organoids self-organize floorplate through BMP-mediated cluster competition
Developmental Cell 59(15):1940-1953.e10
Frith TJR, Briscoe J, Boezio GLM
From signalling to form: the coordination of neural tube patterning
Current Topics in Developmental Biology 159:168-231
Maizels RJ, Snell DM, Briscoe J
Reconstructing developmental trajectories using latent dynamical systems and time-resolved transcriptomics
Cell Systems 15(5):411-424.e9
Ebisuya M, Briscoe J
Timing and tempo in development
Current Opinion in Genetics & Development 86:102202
PubMed Tempo, growth and lineage
Alvarez-Martinez M, Cox LS, Pearson CF, Branchett WJ, Chakravarty P, Wu X, Slawinski H, Al-Dibouni A, Samelis VA, Gabrysová L, Priestnall SL, Suárez-Bonnet A, Mikolajczak A, Briscoe J, Powrie F, O'Garra A
Blimp-1 and c-Maf regulate immune gene networks to protect against distinct pathways of pathobiont-induced colitis
Nature Immunology 25(5):886-901
Zagorski M, Brandenberg N, Lutolf M, Tkacik G, Bollenbach T, Briscoe J, Kicheva A
Assessing the precision of morphogen gradients in neural tube development
Nature Communications 15(1):929
2023
Cox LS, Alvarez-Martinez M, Wu X, Gabrysová L, Luisier R, Briscoe J, Luscombe NM, O'Garra A
Blimp-1 and c-Maf regulate Il10 and negatively regulate common and unique proinflammatory gene networks in IL-12 plus IL-27-driven T helper-1 cells
Wellcome Open Research 8:403
Pezzotta A, Briscoe J
Optimal control of gene regulatory networks for morphogen-driven tissue patterning
Cell Systems 14(11):940-952.e11
Thiery AP, Buzzi AL, Hamrud E, Cheshire C, Luscombe NM, Briscoe J, Streit A
scRNA-sequencing in chick suggests a probabilistic model for cell fate allocation at the neural plate border
eLife 12:e82717
PubMed Gene regulatory networks
Kicheva A, Briscoe J
Control of tissue development by morphogens
Annual Review of Cell and Developmental Biology 39:91-121
Delás MJ, Kalaitzis CM, Fawzi T, Demuth M, Zhang I, Stuart HT, Costantini E, Ivanovitch K, Tanaka EM, Briscoe J
Developmental cell fate choice in neural tube progenitors employs two distinct cis-regulatory strategies
Developmental Cell 58(1):3-17.e8
PubMed Gene regulation
2022
Semprich CI, Davidson L, Amorim Torres A, Patel H, Briscoe J, Metzis V, Storey KG
ERK1/2 signalling dynamics promote neural differentiation by regulating chromatin accessibility and the polycomb repressive complex
PLoS Biology 20(12):e3000221
Frederico B, Martins I, Chapela D, Gasparrini F, Chakravarty P, Ackels T, Piot C, Almeida B, Carvalho J, Ciccarelli A, Peddie CJ, Rogers N, Briscoe J, Guillemot F, Schaefer AT, Saúde L, Reis e Sousa C
DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential
Developmental Cell 57(16):1957-1975.e9
Sáez M, Briscoe J, Rand DA
Dynamical landscapes of cell fate decisions
Interface Focus 12(4):20220002
PubMed Computational approaches
Stapornwongkul KS, Briscoe J
In preprints: morphogens in motion
Development 149(13):dev201066
PubMed Gene regulatory networks
Blassberg R, Patel H, Watson T, Gouti M, Metzis V, Delás MJ, Briscoe J
Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation
Nature Cell Biology 24(5):633-644
Sáez M, Blassberg R, Camacho-Aguilar E, Siggia ED, Rand DA, Briscoe J
Statistically derived geometrical landscapes capture principles of decision-making dynamics during cell fate transitions
Cell Systems 13(1):12-28.e3
Lohoff T, Ghazanfar S, Missarova A, Koulena N, Pierson N, Griffiths JA, Bardot ES, Eng CL, Tyser RCV, Argelaguet R, Guibentif C, Srinivas S, Briscoe J, Simons BD, Hadjantonakis AK, Göttgens B, Reik W, Nichols J, Cai L, Marioni JC
Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis
Nature Biotechnology 40(1):74-85
2021
Sagner A, Zhang I, Watson T, Lazaro J, Melchionda M, Briscoe J
A shared transcriptional code orchestrates temporal patterning of the central nervous system
PLoS Biology 19(11):e3001450
PubMed Tempo, growth and lineage
Rayon T, Maizels RJ, Barrington C, Briscoe J
Single-cell transcriptome profiling of the human developing spinal cord reveals a conserved genetic programme with human-specific features
Development 148(15):dev199711
Ivanovitch K, Soro-Barrio P, Chakravarty P, Jones RA, Bell DM, Mousavy Gharavy SN, Stamataki D, Delile J, Smith JC, Briscoe J
Ventricular, atrial, and outflow tract heart progenitors arise from spatially and molecularly distinct regions of the primitive streak
PLoS Biology 19(5):e3001200
PubMed Other and collaborative
Rayon T, Briscoe J
Cross-species comparisons and in vitro models to study tempo in development and homeostasis
Interface Focus 11(3):20200069
PubMed Tempo, growth and lineage
Hyun I, Bredenoord AL, Briscoe J, Klipstein S, Tan T
Human embryo research beyond the primitive streak
Science 371(6533):998-1000
PubMed Other and collaborative
Exelby K, Herrera-Delgado E, Perez LG, Perez-Carrasco R, Sagner A, Metzis V, Sollich P, Briscoe J
Precision of tissue patterning is controlled by dynamical properties of gene regulatory networks
Development 148(4):dev197566
Ruis P, Van Ly D, Borel V, Kafer GR, McCarthy A, Howell S, Blassberg R, Snijders AP, Briscoe J, Niakan KK, Marzec P, Cesare AJ, Boulton SJ
TRF2-independent chromosome end protection during pluripotency
Nature 589(7840):103-109
2020
Comai GE, Tesarová M, Dupé V, Rhinn M, Vallecillo-García P, da Silva F, Feret B, Exelby K, Dollé P, Carlsson L, Pryce B, Spitz F, Stricker S, Zikmund T, Kaiser J, Briscoe J, Schedl A, Ghyselinck NB, Schweitzer R, Tajbakhsh S
Local retinoic acid signaling directs emergence of the extraocular muscle functional unit
PLoS Biology 18(11):e3000902
Gonzalez Curto G, Der Vartanian A, Frarma YE, Manceau L, Baldi L, Prisco S, Elarouci N, Causeret F, Korenkov D, Rigolet M, Aurade F, De Reynies A, Contremoulins V, Relaix F, Faklaris O, Briscoe J, Gilardi-Hebenstreit P, Ribes V
The PAX-FOXO1s trigger fast trans-differentiation of chick embryonic neural cells into alveolar rhabdomyosarcoma with tissue invasive properties limited by S phase entry inhibition
PLoS Genetics 16(11):e1009164
Herrera-Delgado E, Briscoe J, Sollich P
Tractable nonlinear memory functions as a tool to capture and explain dynamical behaviors
Physical Review Research 2(4):043069
DOI Computational approaches
Rayon T, Stamataki D, Perez-Carrasco R, Garcia-Perez L, Barrington C, Melchionda M, Exelby K, Lazaro J, Tybulewicz VLJ, Fisher EMC, Briscoe J
Species-specific pace of development is associated with differences in protein stability
Science 369(6510):eaba7667
PubMed Tempo, growth and lineage
Briscoe J, Marín O
Looking at neurodevelopment through a big data lens
Science 369(6510):eaaz8627
PubMed Computational approaches
Delás MJ, Briscoe J
Repressive interactions in gene regulatory networks: when you have no other choice
Current Topics in Developmental Biology 139:239-266
PubMed Gene regulatory networks
Small S, Briscoe J
Gradients and tissue patterning
Current Topics in Developmental Biology 137:xv-xvii
PubMed Gene regulatory networks
2019
Guerrero P, Perez-Carrasco R, Zagorski M, Page D, Kicheva A, Briscoe J, Page KM
Neuronal differentiation influences progenitor arrangement in the vertebrate neuroepithelium
Development 146(23):dev176297
Sagner A, Briscoe J
Establishing neuronal diversity in the spinal cord: a time and a place
Development 146(22):dev182154
PubMed Tempo, growth and lineage
Briscoe J
Understanding pattern formation in embryos: experiment, theory, and simulation
Journal of Computational Biology 26(7):696-702
Ahlfors H, Anyanwu N, Pakanavicius E, Dinischiotu N, Lana-Elola E, Watson-Scales S, Tosh J, Wiseman F, Briscoe J, Page K, Fisher EMC, Tybulewicz VLJ
Gene expression dysregulation domains are not a specific feature of Down syndrome
Nature Communications 10(1):2489
PubMed Other and collaborative
Delile J, Rayon T, Melchionda M, Edwards A, Briscoe J, Sagner A
Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord
Development 146(12):dev173807
Bizzarri M, Brash DE, Briscoe J, Grieneisen VA, Stern CD, Levin M
A call for a better understanding of causation in cell biology
Nature Reviews Molecular Cell Biology 20(5):261-262
PubMed Other and collaborative
2018
Metzis V, Steinhauser S, Pakanavicius E, Gouti M, Stamataki D, Ivanovitch K, Watson T, Rayon T, Mousavy Gharavy SN, Lovell-Badge R, Luscombe NM, Briscoe J
Nervous system regionalization entails axial allocation before neural differentiation
Cell 175(4):1105-1118.e17
Frith TJ, Granata I, Wind M, Stout E, Thompson O, Neumann K, Stavish D, Heath PR, Ortmann D, Hackland JO, Anastassiadis K, Gouti M, Briscoe J, Wilson V, Johnson SL, Placzek M, Guarracino MR, Andrews PW, Tsakiridis A
Human axial progenitors generate trunk neural crest cells in vitro
eLife 7:e35786
PubMed Stem cells and bioengineering
Ebisuya M, Briscoe J
What does time mean in development?
Development 145(12):dev164368
PubMed Tempo, growth and lineage
Gabrysová L, Alvarez-Martinez M, Luisier R, Cox LS, Sodenkamp J, Hosking C, Pérez-Mazliah D, Whicher C, Kannan Y, Potempa K, Wu X, Bhaw L, Wende H, Sieweke MH, Elgar G, Wilson M, Briscoe J, Metzis V, Langhorne J, Luscombe NM, O'Garra A
c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells
Nature Immunology 19(5):497-507
PubMed Other and collaborative
Perez-Carrasco R, Barnes CP, Schaerli Y, Isalan M, Briscoe J, Page KM
Combining a toggle switch and a repressilator within the AC-DC circuit generates distinct dynamical behaviors
Cell Systems 6(4):521-530.e3
Placzek M, Briscoe J
Sonic hedgehog in vertebrate neural tube development
International Journal of Developmental Biology 62(1-2-3):221-230
PubMed Gene regulatory networks
Herrera-Delgado E, Perez-Carrasco R, Briscoe J, Sollich P
Memory functions reveal structural properties of gene regulatory networks
PLoS Computational Biology 14(2):e1006003
PubMed Computational approaches
Pusapati GV, Kong JH, Patel BB, Gouti M, Sagner A, Sircar R, Luchetti G, Ingham PW, Briscoe J, Rohatgi R
G protein-coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog
Science Signaling 11(516):eaao5749
PubMed Gene regulatory networks
Sagner A, Gaber ZB, Delile J, Kong JH, Rousso DL, Pearson CA, Weicksel SE, Melchionda M, Mousavy Gharavy SN, Briscoe J, Novitch BG
Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics
PLoS Biology 16(2):e2003127
Blassberg R, Briscoe J
Smoothened sensor places sodium and sterols center stage
Developmental Cell 44(1):3-4
PubMed Gene regulatory networks
Pusapati GV, Kong JH, Patel BB, Krishnan A, Sagner A, Kinnebrew M, Briscoe J, Aravind L, Rohatgi R
CRISPR screens uncover genes that regulate target cell sensitivity to the morphogen Sonic Hedgehog
Developmental Cell 44(1):113-129.e8
PubMed Gene regulatory networks
2017
Zagorski M, Tabata Y, Brandenberg N, Lutolf MP, Tkacik G, Bollenbach T, Briscoe J, Kicheva A
Decoding of position in the developing neural tube from antiparallel morphogen gradients
Science 356(6345):1379-1383
Desplan C, Plachta N, Monteiro A, Guillemin K, Briscoe J
What is the future of developmental biology?
Cell 170(1):6-7
PubMed Other and collaborative
Gouti M, Delile J, Stamataki D, Wymeersch FJ, Huang Y, Kleinjung J, Wilson V, Briscoe J
A gene regulatory network balances neural and mesoderm specification during vertebrate trunk development
Developmental Cell 41(3):243-261.e7
Briscoe J, Kicheva A
The physics of development 100 years after D'Arcy Thompson's 'On Growth and Form'
Mechanisms of Development 145:26-31
PubMed Computational approaches
Sagner A, Briscoe J
Morphogen interpretation: concentration, time, competence, and signaling dynamics
WIREs Developmental Biology 6(4):e271
2016
Perez-Carrasco R, Guerrero P, Briscoe J, Page KM
Intrinsic noise profoundly alters the dynamics and steady state of morphogen-controlled bistable genetic switches
PLoS Computational Biology 12(10):e1005154
PubMed Computational approaches
Demers CJ, Soundararajan P, Chennampally P, Cox GA, Briscoe J, Collins SD, Smith RL
Development-on-chip: in vitro neural tube patterning with a microfluidic device
Development 143(11):1884-1892
PubMed Stem cells and bioengineering
Cohen M, Page KM, Perez-Carrasco R, Barnes CP, Briscoe J
Mathematical models help explain experimental data
Development 143(10):1640-1643
PubMed Computational approaches
Uygur A, Young J, Huycke TR, Koska M, Briscoe J, Tabin CJ
Scaling pattern to variations in size during development of the vertebrate neural tube
Developmental Cell 37(2):127-135
Kutejova E, Sasai N, Shah A, Gouti M, Briscoe J
Neural progenitors adopt specific identities by directly repressing all alternative progenitor transcriptional programs
Developmental Cell 36(6):639-653
2015
Blassberg R, MacRae JI, Briscoe J, Jacob J
Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome
Human Molecular Genetics 25(4):693-705
Briscoe J
Morphogens, modeling and patterning the neural tube: an interview with James Briscoe
BMC Biology 13:5
PubMed Gene regulatory networks
Briscoe J, Small S
Morphogen rules: design principles of gradient-mediated embryo patterning
Development 142(23):3996-4009
PubMed Gene regulatory networks
Cohen M, Kicheva A, Ribeiro A, Blassberg R, Page KM, Barnes CP, Briscoe J
Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms
Nature Communications 6:6709
Gouti M, Metzis V, Briscoe J
The route to spinal cord cell types: a tale of signals and switches
Trends in Genetics 31(5):282-289
PubMed Stem cells and bioengineering
Kicheva A, Briscoe J
Developmental pattern formation in phases
Trends in Cell Biology 25(10):579-591
Kong JH, Yang L, Dessaud E, Chuang K, Moore DM, Rohatgi R, Briscoe J, Novitch BG
Notch activity modulates the responsiveness of neural progenitors to Sonic hedgehog signaling
Developmental Cell 33(4):373-387
PubMed Gene regulatory networks
2014
Cohen M, Page KM, Perez-Carrasco R, Barnes CP, Briscoe J
A theoretical framework for the regulation of Shh morphogen-controlled gene expression
Development 141(20):3868-3878
PubMed Computational approaches
Goggolidou P, Stevens JL, Agueci F, Keynton J, Wheway G, Grimes DT, Patel SH, Hilton H, Morthorst SK, DiPaolo A, Williams DJ, Sanderson J, Khoronenkova SV, Powles-Glover N, Ermakov A, Esapa CT, Romero R, Dianov GL, Briscoe J, Johnson CA, Pedersen LB, Norris DP
ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis
Development 141(20):3966-3977
PubMed Other and collaborative
Gouti M, Tsakiridis A, Wymeersch FJ, Huang Y, Kleinjung J, Wilson V, Briscoe J
In vitro generation of neuromesodermal progenitors reveals distinct roles for Wnt signalling in the specification of spinal cord and paraxial mesoderm identity
PLoS Biology 12(8):e1001937
PubMed Stem cells and bioengineering
Jacob J, Ribes V, Moore S, Constable SC, Sasai N, Gerety SS, Martin DJ, Sergeant CP, Wilkinson DG, Briscoe J
Valproic acid silencing of ascl1b/Ascl1 results in the failure of serotonergic differentiation in a zebrafish model of fetal valproate syndrome
Disease Models & Mechanisms 7(1):107-117
PubMed Other and collaborative
Kicheva A, Bollenbach T, Ribeiro A, Valle HP, Lovell-Badge R, Episkopou V, Briscoe J
Coordination of progenitor specification and growth in mouse and chick spinal cord
Science 345(6204):1254927
Sasai N, Kutejova E, Briscoe J
Integration of signals along orthogonal axes of the vertebrate neural tube controls progenitor competence and increases cell diversity
PLoS Biology 12(7):e1001907
PubMed Gene regulatory networks
2013
Briscoe J, Thérond PP
The mechanisms of Hedgehog signalling and its roles in development and disease
Nature Reviews Molecular Cell Biology 14(7):416-429
PubMed Gene regulatory networks
Briscoe J, Vincent JP
Hedgehog threads to spread
Nature Cell Biology 15(11):1265-1267
PubMed Gene regulatory networks
Cohen M, Briscoe J, Blassberg R
Morphogen interpretation: the transcriptional logic of neural tube patterning
Current Opinion in Genetics & Development 23(4):423-428
Gerety SS, Breau MA, Sasai N, Xu Q, Briscoe J, Wilkinson DG
An inducible transgene expression system for zebrafish and chick
Development 140(10):2235-2243
PubMed Other and collaborative
Jacob J, Kong J, Moore S, Milton C, Sasai N, Gonzalez-Quevedo R, Terriente J, Imayoshi I, Kageyama R, Wilkinson DG, Novitch BG, Briscoe J
Retinoid acid specifies neuronal identity through graded expression of Ascl1
Current Biology 23(5):412-418
PubMed Gene regulatory networks
Kahane N, Ribes V, Kicheva A, Briscoe J, Kalcheim C
The transition from differentiation to growth during dermomyotome-derived myogenesis depends on temporally restricted hedgehog signaling
Development 140(8):1740-1750
PubMed Other and collaborative
Liu JAJ, Wu MH, Yan CH, Chau BKH, So H, Ng A, Chan A, Cheah KSE, Briscoe J, Cheung M
Phosphorylation of Sox9 is required for neural crest delamination and is regulated downstream of BMP and canonical Wnt signaling
Proceedings of the National Academy of Sciences USA 110(8):2882-2887
PubMed Other and collaborative
Moore S, Ribes V, Terriente J, Wilkinson D, Relaix F, Briscoe J
Distinct regulatory mechanisms act to establish and maintain Pax3 expression in the developing neural tube
PLoS Genetics 9(10):e1003811
PubMed Gene regulation
Panovska-Griffiths J, Page KM, Briscoe J
A gene regulatory motif that generates oscillatory or multiway switch outputs
Journal of the Royal Society Interface 10(79):20120826
PubMed Computational approaches
Tozer S, Le Dréau G, Marti E, Briscoe J
Temporal control of BMP signalling determines neuronal subtype identity in the dorsal neural tube
Development 140(7):1467-1474
2012
Balaskas N, Ribeiro A, Panovska J, Dessaud E, Sasai N, Page KM, Briscoe J, Ribes V
Gene regulatory logic for reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube
Cell 148(1-2):273-284
Briscoe J, Rohatgi R
Singapore signalling: the 2012 hedgehog pathway cocktail
EMBO Reports 13(7):580-583
PubMed Gene regulatory networks
Briscoe J, Sharpe J
Genetics of systems biology
Current Opinion in Genetics & Development 22(6):523-526
PubMed Computational approaches
Bushati N, Briscoe J
Regulation of neuronal subtype identity in the vertebrate neural tube
eLS (John Wiley & Sons)
DOI Gene regulatory networks
Kicheva A, Bollenbach T, Wartlick O, Jülicher F, Gonzalez-Gaitan M
Investigating the principles of morphogen gradient formation: from tissues to cells
Current Opinion in Genetics & Development 22(6):527-532
PubMed Gene regulatory networks
Kicheva A, Cohen M, Briscoe J
Developmental pattern formation: insights from physics and biology
Science 338(6104):210-212
PubMed Computational approaches
Le Dréau G, Garcia-Campmany L, Rabadán MA, Ferronha T, Tozer S, Briscoe J, Marti E
Canonical BMP7 activity is required for the generation of discrete neuronal populations in the dorsal spinal cord
Development 139(2):259-268
PubMed Gene regulatory networks
Matheu A, Collado M, Wise C, Manterola L, Cekaite L, Tye AJ, Cañamero M, Bujanda L, Schedl A, Cheah KSE, Skotheim RI, Lothe RA, López de Munain A, Briscoe J, Serrano M, Lovell-Badge R
Oncogenicity of the developmental transcription factor Sox9
Cancer Research 72(5):1301-1315
PubMed Other and collaborative
Rabadán MA, Cayuso J, Le Dréau G, Cruz C, Barzi M, Pons S, Briscoe J, Martí E
Jagged2 controls the generation of motor neuron and oligodendrocyte progenitors in the ventral spinal cord
Cell Death and Differentiation 19(2):209-219
PubMed Gene regulatory networks
Sasai N, Briscoe J
Primary cilia and graded Sonic Hedgehog signaling
WIREs Developmental Biology 1(5):753-772
PubMed Gene regulatory networks
2011
Bangs F, Antonio N, Thongnuek P, Welten M, Davey MG, Briscoe J, Tickle C
Generation of mice with functional inactivation of talpid3, a gene first identified in chicken
Development 138(15):3261-3272
PubMed Other and collaborative
Bushati N, Smith J, Briscoe J, Watkins C
An intuitive graphical visualization technique for the interrogation of transcriptome data
Nucleic Acids Research 39(17):7380-7389
PubMed Computational approaches
Chen Y, Sasai N, Ma G, Yue T, Jia J, Briscoe J, Jiang J
Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of Smoothened
PLoS Biology 9(6):e1001083
Escudero LM, Costa LdaF, Kicheva A, Briscoe J, Freeman M, Babu MM
Epithelial organisation revealed by a network of cellular contacts
Nature Communications 2:526
PubMed Computational approaches
Gouti M, Briscoe J, Gavalas A
Anterior Hox genes interact with components of the neural crest specification network to induce neural crest fates
Stem Cells 29(5):858-870
PubMed Other and collaborative
Stamataki D, Holder M, Hodgetts C, Jeffery R, Nye E, Spencer-Dene B, Winton DJ, Lewis J
Delta1 expression, cell cycle exit, and commitment to a specific secretory fate coincide within a few hours in the mouse intestinal stem cell system
PLoS ONE 6(9):e24484
PubMed Other and collaborative
2010
Briscoe J, Lawrence PA, Vincent JP (editors)
Generation and Interpretation of Morphogen Gradients
Cold Spring Harbor Laboratory Press, New York
Gene regulatory networks
Cox B, Briscoe J, Ulloa F
SUMOylation by Pias1 regulates the activity of the Hedgehog dependent Gli transcription factors
PLoS ONE 5(8):e11996
PubMed Gene regulatory networks
Cruz C, Ribes V, Kutejova E, Cayuso J, Lawson V, Norris D, Stevens J, Davey M, Blight K, Bangs F, Mynett A, Hirst E, Chung R, Balaskas N, Brody SL, Marti E, Briscoe J
Foxj1 regulates floor plate cilia architecture and modifies the response of cells to Sonic hedgehog signalling
Development 137(24):4271-4282
PubMed Gene regulatory networks
Dessaud E, Ribes V, Balaskas N, Yang LL, Pierani A, Kicheva A, Novitch BG, Briscoe J, Sasai N
Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen Sonic hedgehog
PLoS Biology 8(6):e1000382
Ribes V, Balaskas N, Sasai N, Cruz C, Dessaud E, Cayuso J, Tozer S, Yang LL, Novitch B, Marti E, Briscoe J
Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube
Genes & Development 24(11):1186-1200
PubMed Gene regulatory networks
Scott CE, Wynn SL, Sesay A, Cruz C, Cheung M, Gomez Gaviro MV, Booth S, Gao B, Cheah KSE, Lovell-Badge R, Briscoe J
SOX9 induces and maintains neural stem cells
Nature Neuroscience 13(10):1181-1189
PubMed Other and collaborative
Zhu D, Jarmin S, Ribeiro A, Prin F, Xie SQ, Sullivan K, Briscoe J, Gould AP, Marelli-Berg FM, Gu Y
Applying an adaptive watershed to the tissue cell quantification during T-cell migration and embryonic development
Methods in Molecular Biology 616:207-228
PubMed Computational approaches
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